Cyclic AMP, Urine
|Epic Code:||LAB6051||Epic Name:||Cyclic AMP, Urine|
|Turnaround Time:||Specimens are sent to reference laboratory Mon-Sat; results are reported in 2-10 days.|
This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
|Specimen:||Urine, random or timed collection|
|Optimal Volume:||Submit entire collection; analysis requires 1 mL|
|Container:||Plastic leakproof container, sterile. Alternate: 3 L plastic jug.|
|Collection Instructions:||Unpreserved random urine is preferred. Timed urine is acceptable if refrigerated during collection.|
Processing and Shipping
|Specimen Processing:||Add 1 gram boric acid/100 mL urine. Mix collection well before aliquot is taken. Aliquot 5 mL, 1 mL minimum into two ARUP transport tubes. Freeze immediately. Record total volume and collection time interval on aliquot tubes.|
|Shipping Instructions:||Ship on dry ice.|
|Test Performed at or Referral Lab||Lab Sendouts (ARUP)|
|Referral Lab number:||70485 (CAMP-U)|
Cyclic AMP, Urine: 0.5-10.0 nmol/mL
Cyclic adenosine monophosphate (cAMP) mediates the action of a number of cell membrane active hormones. Through their receptors, these hormones activate adenylate cyclase to produce cAMP from adenosine triphosphate (ATP). cAMP in turn activates a variety of protein kinases within the cytosol.
cAMP excretion rates provide a reliable aid in the assessment of parathyroid function in physiological and pathological conditions. Although urinary excretion of cAMP is increased in hyperparathyroidism, significant overlap with normal occurs. The nephrogenous component is a much more specific indicator. Patients with hypercalcemia of malignancy may also have increased nephrogenous cAMP, presumably due to circulating PTH-like activity (PTH-related peptide or PTHrP).
Measurement of both urinary and plasma cAMP levels are required for the calculation of nephrogenous cAMP, whereas only urinary cAMP is necessary for total cAMP excretion. Determination of the creatinine clearance allows all results to be expressed as a function of Glomerular alteration rate.
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