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Factor 12 Activity


Sunquest Code:F12  
Epic Code:LAB310Epic Name:FACTOR 12 ASSAY
Order Instructions:Outreach clients order: NCBAT
Synonyms:Factor XII Activity; Hageman Factor
Methodology:APTT clotting time correction of factor 12 deficient plasma. Patient dilutions are compared to a known set of standard dilutions and a percentage is determined.
CPT Code:85280
Turnaround Time:Turnaround time is 4-8 hours if received during lab hours (see Associated Link). With pre-notification, stats are done within 1 hr after receipt in the laboratory.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens



Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube.
Container:Blue Na Citrate, 3.2% - fill to fill line on tube.
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tube.


Processing and Shipping

Specimen Processing:See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab Special Coagulation  (UMMC-East Bank)


Interpretive

Critical Range:Less than 10%
Reference Range:

0 d

34-112%

1-4 d

33-73%

5-29 d

29-65%

30-89 d

33-65%

90-179 d

44-88%

180-364 d

58-96%

1 y & older

50-186%

 

 

Use:Factor 12 is a "contact" factor (initiation of coagulation by surface contact). A deficiency causes a prolonged aPTT (strikingly prolonged if a severe deficiency), but does NOT cause a clinical bleeding tendency.


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