Treponema Antibody

Sunquest Code:TREPAB  
Epic Code:LAB3791Epic Name:Treponema Antibody
Synonyms:Syphilis Antibody; Treponema Pallidum Antibody; STI; RPR; STD; TREPAB; Anti-Treponema
Methodology:Chemiluminescent immunoassay (CLIA)
Turnaround Time:Performed Mon-Fri; results are reported within 2 days.
Associated Links:

Syphilis Serology Algorithm

Collection Instructions

Optimal Volume:3 mL
Minimum Volume:2.2 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Hyperlipemic, particulate matter, bacterial contamination and grossly hemolyzed samples.
Contraindications:This test (TREPAB) is not used to test CSF specimens; see VDRL, Cerebrospinal.

Processing and Shipping

Specimen Processing:Centrifuge and leave sample in serum separator tube (preferred). Alternately, aliquot 1.5 mL, 1 mL minimum. Store in refrigerator up to 7 days. Alternatively, freeze at 20 C or below.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Specialty Core  (UMMC-East Bank)


Reference Range:


Less than 0.9




Greater than 1.1



Use:Use for screening for exposure to Treponema pallidum. The Anti-Treponema screening test tends to remain positive for life, and therefore does not distinguish between active and post syphilis infections. All positive and equivocal results will automatically reflex to a non-specific Rapid Plasma Reagin (RPR) test. If the Anti-Treponema is positive, and the RPR is reactive, this is presumptive evidence of current infection, inadequately treated infection, persistent infection or reinfection. If the Anti-Treponema is positive and the RPR is negative, then a second Treponema specific test, Treponema pallidum particle agglutination (TP-PA) will be performed to determine whether the anti-Treponema antibody is falsely positive or is detecting early infection. If the latter is suspected, repeat testing in approximately 2 weeks is recommended.

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