Vitamin A


Sunquest Code:VITAA  
Epic Code:LAB580Epic Name:Vitamin A
Synonyms:Retinol
Methodology:High performance liquid chromatography
CPT Code:84590
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel) (Green (lithium heparin, no gel), Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel))
Patient Preparation:Fast overnight (12 hours). Avoid alcohol for 1 day prior to collection.
Causes for Rejection:Whole blood or body fluids other than serum or plasma. Room temperature specimens.


Processing and Shipping

Specimen Processing:Within 1 hour of collection, centrifuge and aliquot 1 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80525


Interpretive

Reference Range:

Vitamin A (Retinol)

      0-1 mo

      2 mo -12 y:

      13-17 y

      18 y and older

 

0.18-0.50 mg/L

0.20-0.50 mg/L

0.26-0.70 mg/L

0.30-1.20 mg/L

Retinyl Palmitate, all ages

0.00-0.10 mg/L

 

 

Use:Serum retinol is typically maintained until hepatic stores are almost depleted. Values greater than 0.30 mg/L represent adequate liver stores, whereas values less than 0.10 mg/L indicate deficiency. Samples that come in contact with plastic tubing or have been exposed to excessive light may show low results. Vitamin A toxicity occurs when retinol concentration exceeds the capacity of retinol binding protein (RBP). Individuals with compromised renal function can retain RBP and may, therefore, have moderate retinol elevations. Drugs which interfere with vitamin A analysis include probucol (Lorelco). This assay does not measure other Vitamin A metabolites such as retinaldehyde or retinoic acid.


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