Acetylcholine Receptor Blocking Antibody


Sunquest Code:ACRBLK  
Epic Code:LAB838Epic Name:Acetylcholine Receptor Blocking Aby
Synonyms:AChR Blocking Antibody; Anticholinesterase Antibody
Methodology:Flow cytometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Severely lipemic; contaminated or hemolyzed specimens.


Processing and Shipping

Specimen Processing:Separate serum from cells within 2 hours of collection. Centrifuge and aliquot 1 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: After separation from cells: 2 hours at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:99580


Interpretive

Reference Range:

Negative

0-26% blocking;

Indeterminate

27-41% blocking

Positive

42% or greater blocking

 

 

Use:Approximately 85-90% of patients with myasthenia gravis (MG) express antibodies to the acetylcholine receptor (AChR), which can be divided into binding, blocking and modulating antibody. Binding antibody can activate complement and lead to loss of AChR. Blocking antibody may impair AChR binding to the receptor leading to poor muscle contraction. Modulating antibody causes receptor endocytosis resulting in loss of AChR expression, which correlates most closely with clinical severity of disease. Approximately 10-15% of individuals with confirmed myasthenia gravis have no measurable binding, blocking or modulating antibody.


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