Aluminum, Serum


Sunquest Code:AL  
Epic Code:LAB665Epic Name:Aluminum
Methodology:Inductively coupled plasma/mass spectrometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:1.2 mL
Container:Trace Element, Serum (DB)
Patient Preparation:Diet, medication and nutritional supplements may introduce interfering substances. Patient should be encouraged to discontinue nutritional supplements, vitamins, minerals and non-essential over-the-counter medications (upon the advice of their physician).
Causes for Rejection:Plasma. Specimens that are not separated from the red cels or clot within 2 hours. Specimens collected in containers other than specified. Specimens transported in containers other than specified.


Processing and Shipping

Specimen Processing:Within 2 hours of collection, centrifuge and aliquot, 2 mL, 0.5 mL minimum into metal free vial. Do not use glass pipets, glass vials or wooden applicator sticks. Store at room temperature.
Shipping Instructions:Ship at room temperature.
Stability:If the speicmen is drawn and stored in the appropriate container, the trace element values do not change with time.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:99266


Interpretive

Reference Range:0-15 ug/L
Serum aluminum greater than 50 ug/L is consistent with overload and may correlate with toxicity.
Use:

The average daily intake of this ubiquitous element from food and water sources ranges from 2-15 mg. Healthy people do not develop aluminum toxicity because of natural protection mechanisms. Only a small fraction of the ingested aluminum is absorbed in healthy people. However, when the natural controls are circumvented or compromised (as in iatrogenic exposures resulting from medications, dialysis or intravenous fluid administration) aluminum exposure must be controlled to prevent toxicity. Dialysis dementia and renal osteodystrophy have been associated with aluminum toxicity. Renal functional impairment decreases aluminum excretion, promoting aluminum accumulation in the body. Well documented reports of neuromuscular disorders and osteomalacia have appeared that are attributable to aluminum-laden dialysates.

 

Aluminum has been linked to Alzheimer’s disease because it has been noted that this metal accumulates in neurofibrillary tangles. The relationship (if any) of aluminum to the pathogenesis of this disease is poorly understood; a causal relationship to Alzheimer’s disease is unlikely.

 



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