Beta-Hydroxybutyric Acid


Sunquest Code:BOHBU  
Epic Code:LAB3330Epic Name:BETA HYDROXYBUTYRATE LEVEL
Order Instructions:If received from a pediatric unit at UMMC order Ketones by Meter.
Synonyms:Beta-Hydroxybutyrate; Beta Hydroxybutyric Acid
Methodology:Enzymatic
CPT Code:82010
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-3 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Gray (sodium fluoride + potassium oxalate), Purple (EDTA), Red (no gel))


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1 mL, 0.2 mL minimum. Store in refrigerator up to one week; otherwise freeze.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80045 (B-OH)


Interpretive

Reference Range:0.0-3.0 mg/dL
Use:

Ketosis is the accumulation in the body of the ketone bodies: acetone, acetoacetate, and beta-hydroxybutyric acid (b-HB). It is a common feature in acutely ill patients, such as those suffering from starvation, acute alcohol abuse, or diabetes mellitus and may result in severe, life-threatening metabolic acidosis. The presence and degree of ketosis can be determined by measuring blood levels of b-HB. Ordinarily, b-HB is the ketone present in the greatest amount in serum (approximately 75%). During ketosis, the percentage of b-HB increases even more, making it a more reliable index of ketoacidosis, than the other two ketones. In diabetes, the measurement of b-HB, as well as serum glucose, is needed for assessment of the severity of diabetic coma. Moreover, insulin requirements are often based on the extent of the existing hyperketonemia shown by the blood levels of b-HB.

 



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