Renin Activity to ARUP


Sunquest Code:RENIN  
Epic Code:LAB532Epic Name:Renin Activity
Methodology:Radioimmunoassay
CPT Code:84244
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-2 days.


Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:2.6 mL
Collection Instructions:Whole blood specimens should not be chilled or placed on ice because of irreversible cryoactivation of prorenin can occur leading to falsely elevated results.
Patient Preparation:Collect mid-morning after patient has been sitting, standing or walking for at least 2 hours and seated for 5-15 minutes. Normal sodium diet (100-200 mEq/day) for at least three days. Receiving no medications known to affect renin-aldosterone system.
Contraindications:Refrigerated specimen; serum, heparin, citrate or oxalate plasma, hemolyzed specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 2 mL, 1.2 mL minimum ASAP after collection. Freeze immediately.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:70105


Interpretive

Reference Range:

 

ng/mL/h

Adult, Normal Sodium Diet

Supine

0.2-1.6

Upright

0.5-4.0

Children, Normal Sodium Diet

1-12 mo

2.4-37.0

13 mo-3 y

1.7-11.2

4-5 y

1.0-6.5

6-10 y

0.5-5.9

11-15 y

0.5-3.3

Newborn (1-7 days)

2.0-35.0

Cord Blood

4.0-32.0

 

Note: Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma rennin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased. Renin, Direct measures the actual concentration of rennin in the plasma, and therefore is not dependent on angiotensinogen concentration.

 

Use:

The measurement of plasma renin activity (PRA) may be useful in determining whether hypertension is due to primary hyperaldosteronism or renal vascular disease. PRA is suppressed in primary hyperaldosteronism, whereas PRA and aldosterone are both elevated in secondary hyperaldosteronism (renovascular hypertension). The plasma renin and aldosterone ratio is used to screen patients with hypokalemia and possible hyperaldosteronism.

 



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