Rubella Antibody, IgM


Sunquest Code:RUIGM  
Epic Code:LAB6358Epic Name:Rubella IgM
Synonyms:German Measles Antibody Titer, IgM
Methodology:Multiplex flow immunoassay
CPT Code:----------CPTCODES HERE----------
Turnaround Time:Performed Mon-Fri; results reported the same day.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.9 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel))
Causes for Rejection:Gross hemolysis


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.35 mL minimum. Store in refrigerator up to 7 days.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Specialty Core  (UMMC-East Bank)


Interpretive

Reference Range:

Negative

Less than or equal to 0.8 AI

Equivocal

0.9 – 1.0 AI

Positive

1.1 AI or greater

Antibody index (AI) values reflect qualitative changes in antibody concentration that cannot be directly associated with clinical condition or disease state.

 

Use:Aid in diagnosis of primary rubella infection in pregnant women and congenital rubella infection in neonates. IgM antibodies become detectable in a few days after the onset of signs and symptoms and reach peak levels in 7-10 days. These antibodies persist, but rapidly diminish in concentration over the next 4-5 weeks until the antibody is no longer clinically detectable. The present of IgM antibody in a single specimen suggests that the patient has recently experienced a rubella infection. In most cases, the infection probably occurred within the preceding 1-3 months. Rubella IgM antibody in a newborn's serum suggests congenital infection since IgM from the mother is not transferred to the infant across the placenta. The infected infant, in contrast to a woman with prenatal rubella, may continue to produce rubella-specific IgM for several months.


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