Deamidated Gliadin Antibodies, IgA and IgG


Sunquest Code:DGPABY  
Epic Code:LAB5570Epic Name:Deamidated Gliadin Peptide Ab IgA and IgG
Synonyms:Anti-Gliadin (Deamidated) Antibody; Celiac Disease; Coeliac Disease, Malabsorption; Deamidated Gliadin Peptide Antibodies
Methodology:FEIA (by ImmunoCAP)
CPT Code:83516, 83516
Turnaround Time:Performed once a week; results are reported the same day.


Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel))
Causes for Rejection:Hemolyzed, lipemic or microbially contaminated samples. Samples not separated from cells within 2 hours of collection.


Processing and Shipping

Specimen Processing:Within 2 hours centrifuge and aliquot 0.5 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Endocrine  (UMMC-East Bank)


Interpretive

Reference Range:

Deamidated Gliadin Antibody IgA

Less than 7 Units/mL

Negative

7-10  Units/mL

Equivocal

Greater than 10 Units/mL

Positive

 

Deamidated Gliadin Antibody IgG

Less than 7 Units/mL

Negative

7-10  Units/mL

Equivocal

Greater than 10 Units/mL

Positive

Positive test results for deamidated gliadin antibodies, IgA or IgG, are consistent with the diagnosis of celiac disease.

Negative results indicate a decreased likelihood of celiac disease.

Decreased levels of deamidated gliadin antibodies, IgA or IgG, following treatment with a gluten-free diet are consistent with adherence to the diet. Persistence of high levels of antibodies following dietary treatment suggests poor adherence to the diet or the presence of refractory disease.

 

Use:

Evaluating patients suspected of having celiac disease. This includes patients with symptoms compatible with celiac disease, patients with atypical symptoms, and individuals at increased risk of celiac disease.

 

Evaluating the response to treatment with a gluten-free diet.

 



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