Carnitine, Free and Total (Includes Carnitine, Esterified)


Sunquest Code:CARN  
Epic Code:LAB3357Epic Name:Carnitine Free and Total
Methodology:Tandem mass spectrometry
Test Includes:Total carnitine, free carnitine, L. Carnitine free and total, and esterified (acyl) carnitine (calculation).
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.6 mL
Container:Green (sodium heparin, no gel) on ICE (Green (lithium heparin) on ICE, Red (no gel) on ICE)
Causes for Rejection:Room temperature specimens. Refrigerated specimens greater than 12 hours old. Avoid hemolysis.


Processing and Shipping

Specimen Processing:Separate plasma from cells ASAP or within 2 hours of collection. Centrifuge and aliquot 0.5 mL, 0.2 mL minimum and freeze immediately.
Note: Storage at room temperature is unacceptable. Sample must be maintained at refrigerated temperature (up to 12 hours) or frozen (preferred).
Shipping Instructions:Ship on dry ice. CRITICAL FROZEN. Separate specimens must be submitted when mulriple tests are ordered.
Stability:12 hours refrigerated; 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80068


Interpretive

Reference Range:

 

 

Age

Free Carnitine

µmol/L

Total Carnitine

µmol/L

Esterified Carnitine

µmol/L

Ratio Esterified: Free

1 - 31 d

15-55

21-83

4-29

0.2-0.8

32 d – 12 mo

29-61

38-73

7-24

0.1-0.8

13 mo – 6 y

25-55

35-90

4-36

0.1-0.8

7 – 20 y

22-63

31-78

3-38

0.1-0.9

21 y or older

25-60

34-86

5-29

0.1-1.0

 

 

Use:Carnitine deficiency has been suggested as the primary cause of human lipid storage myopathy, including Carnitine deficiency (type 1 lipid storage myopathy), Carnitine-palmityltransferase (CPT) deficiency, and Pyruvate-decarboxylase deficiency. Deficiencies have also been reported in premature infants and in patients with cirrhosis, renal failure, and long-term nutritional therapy (TPN). Serum carnitine levels increase during attacks of myoglobinuria.


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