Copper, Urine

Sunquest Code:UCU  
Epic Code:LAB3824Epic Name:Copper Urine
Methodology:Inductively coupled plasma/mass spectrometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

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Urine Collection Procedure

Collection Instructions

Specimen:Urine, 24 hour collection
Optimal Volume:Submit entire 24 hour collection; analysis requires 1 mL
Container:3 L plastic jug (Plastic leakproof container, sterile)
Collection Instructions:Specimen should be refrigerated during collection. ARUP studies indicate that refrigeration of urine alone, during and after collection preserves specimens adequately, if tested within 14 days of collection.
Patient Preparation:Diet, medication and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals and non-essential over-the-counter medications (upon the advice of their physician).
Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.
Causes for Rejection:Urine collected within 72 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRS studies). Acid preserved urine. Samples not aliquoted into ARUP metal-free plastic vials.

Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Aliquot 8 mL, 1 mL minimum into 2 ARUP Blue top metal free plastic vials. Regular aliquot tubes will be rejected. Store in refrigerator. Record total volume and collection time interval on transport tube and on request form.
Shipping Instructions:Ship at refrigerated temperature.
Stability:1 week at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:20461


Reference Range:
Copper, Urine-per volume 0.3-3.2 µg/dL
Copper, Urine-per 24 hr 3.0-45.0 µg/d
Copper, Urine-ratio to CRT 10.0-45.0 µg/g CRT
Use:Copper deficiency is associated with fetal prematurity, malnutrition, malabsorption, chronic diarrhea, and hyperalimentation with mineral-deficient infusates. Studies have also indicated an association with subclinical copper deficiency and coronary heart disease. Menkes' steely hair syndrome is rare, x-linked inheritable form of copper deficiency. acute toxicity is usually due to ingestion. In patients with Wilson's disease, accumulation is chronic with clinical presentation usually between 6-40 years of age. Urinary copper excretion is increased (usually exceeding 100 ug/day) Ceruloplasmin is decreased, resulting in decreased total serum copper levels. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.

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