Factor 2 Activity


Sunquest Code:F2  
Epic Code:LAB303Epic Name:Factor 2 Assay
Synonyms:Prothrombin Assay; Factor II Activity
Methodology:Thromboplastin clotting time correction of Factor 2 deficient plasma. Patient dilutions are compared to a known set of standard dilutions and a percentage is determined.
CPT Code:----------CPTCODES HERE----------
Turnaround Time:Turnaround time is 4-8 hours if received during lab hours (See Associated Link). With pre-notification, stats are done within 1 hr after receipt in the laboratory.
Special Instructions:This test is different from the Prothrombin 20210 Mutation PCR test.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens



Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube.
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tube or clotted specimens.


Processing and Shipping

Specimen Processing:See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab Special Coagulation  (UMMC-East Bank)


Interpretive

Critical Range:Less than 10%
Reference Range:

Less than 1 d

28-78%

1-4 d

37-59%

5-29 d

48-78%

30-89 d

51-85%

90-179 d

60-90%

180-364 d

74-102%

1 y and older

60-140%

 

 

Therapeutic Range:With Coumadin therapy: 15-25%
Use:Factor 2 is a common pathway factor. A deficiency can result in a moderately severe bleeding disorder. Also used to monitor Coumadin therapy in patients with lupus inhibitors. Factor 2 is dependent on Vitamin K for its carboxylation. It is decreased in Vitamin K deficiency/Coumadin therapy. Prothrombin is the clinically critical factor that needs to be reduced to have effective anticoagulation with Coumadin. Therapeutic level for Coumadin therapy is 15-25%.


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