Protein C Activity


Sunquest Code:PCCH  
Epic Code:LAB489Epic Name:Protein C Chromogenic
Synonyms:Protein C Chromogenic
Methodology:Chromogenic (synthetic substrate) activity assay
CPT Code:85303
Turnaround Time:Specimen is accepted and processed 24 hours/day, 7 days/week. Test is performed 2-3 times/week; results are reported within 3-5 days.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens



Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube.
Collection Instructions:See link to Specimen Collectionand Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tube or clotted specimens.


Processing and Shipping

Specimen Processing:See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab Special Coagulation  (UMMC-East Bank)


Interpretive

Critical Range:

Less than 20% (for 5 days and older).

 

 

Reference Range:

 

Protein C Chromogenic

Newborn

14-42%

1 - 4 d

26-44%

5 - 29 d

31-53%

30 – 89 d

32-54%

90-179 d

41-67%

180 – 364 d

48-70%

1 – 5 y

40-92%

6 – 10 y

45-93%

11 – 16 y

55-111%

17 y and older

70-170%

 

 

Use:Protein C, along with its cofactor Protein S, acts as a potent anticoagulant by destroying activated Factors 5 and 8. It is Vitamin K dependent, therefore it is decreased in warfarin therapy or Vitamin K deficiency. Protein C deficiency is a risk factor for thromboembolism. Severe deficiency may cause purpura fulminans in neonates. It is best not to test for Protein C deficiency during an acute thrombotic event. The Protein C Chromogenic (activity) assay determines amount of functional Protein C.


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