Factor 10 Activity


Sunquest Code:F10  
Epic Code:LAB3458Epic Name:Factor 10 Assay
Synonyms:Stuart Prower Factor; Factor X Activity
Methodology:Thromboplastin clotting time correction of Factor 10 deficient plasma. Patient dilutions are compared to a known set of standard dilutions and a percentage is determined.
CPT Code:85260
Turnaround Time:Turnaround time is 4-8 hours if received during lab hours (See Associated Link). With pre-notification, stats are done within 1 hr after receipt in the laboratory.
Special Instructions:THIS TEST IS NOT TO BE USED TO MONITOR HEPARIN THERAPY. THE HEPARIN (ANTI-XA) ASSAY IS USED TO MONITOR HEPARIN. This test is not recommended for monitoring Coumadin therapy in patients with Lupus-like inhibitors. Chromogenic Factor 10 or Factor 2 is used to monitor Coumadin therapy in patients with Lupus inhibitors.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens



Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube.
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tube or clotted specimens.


Processing and Shipping

Specimen Processing:See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab Special Coagulation  (UMMC-East Bank)


Interpretive

Critical Range:Less than 10%
Reference Range:

Less than 1 d

22-72%

1-4 d

26-54%

5-29 d

34-64%

30-89 d

45-73%

90-179 d

53-89%

180-364 d

58-98%

1 y and older

60-140%

 

 

Use:Factor 10 is a common pathway factor. A deficiency can result in a moderately severe bleeding disorder. Factor 10 is dependent on Vitamin K for its carboxylation. It should not, however, be used to monitor Coumadin therapy in patients with Lupus-like inhibitors. Since Prothrombin is the clinically critical factor that needs to be reduced to have effective anticoagulation with Coumadin, Factor 2 is recommended. For laboratories that cannot assay an accurate Factor 2 clotting test in the presence of a lupus inhibitor, Chromogenic Factor 10 is recommended.


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