Amitriptyline and Nortriptyline


Sunquest Code:AMI  
Epic Code:LAB3279Epic Name:Amitriptyline Nortriptyline and Total
Synonyms:Elavil
Methodology:Liquid chromatography/Tandem mass spectrometry
CPT Code:80335
Test Includes:Amitriptyline and Nortriptyline (metabolite)
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 3 days.
Compliance:

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:1.4 mL
Container:Red (no gel) (Green (lithium heparin, no gel), Green (sodium heparin, no gel))
Collection Instructions:With patient at steady-state, collect sample immediately prior to next dose (trough).


Processing and Shipping

Specimen Processing:Centrifuge and transfer serum/plasma with a plastic pipet. Aliquot 2 mL, 0.6 mL minimum into plastic vial. Store at room temperature.
Shipping Instructions:Ship at room temperature up to 3 days; alternately refrigerate or freeze.
Test Performed at or Referral Lab Lab Sendouts  (MedTox)
Referral Lab number:11


Interpretive

Critical Range:Amitriptyline + Metabolite: 1000 ng/mL; Nortriptyline: 500 ng/mL
Reference Range:Amitriptyline + Metabolite: 80-200 ng/mL; Nortriptyline: 50-150 ng/mL
Use:Therapeutic drug monitoring and assess toxicity.


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