Cytology, Urinary Tract


Sunquest Code:NGNCTCoPath Code:NGYN
Epic Code:LAB4600Epic Name:Cytology Non Gyn
Sunquest Code (non-Epic sites):COPATH  
Synonyms:Urine Cytology; Decoy Cells
Methodology:Preparation, staining and microscopic evaluation
CPT Code:88112, 88112-26
Turnaround Time:Performed Mon-Fri, 0800-1500; results are reported within 1-2 days.
Special Instructions:Provide pertinent clinical history.


Collection Instructions

Specimen:Voided (preferred) or catheterized urine, intraoperative washings/brushings of urinary bladder, urethra, ureters or renal pelvis
Optimal Volume:10 mL or more
Container:ThinPrep UroCyte urine collection kit (Plastic leakproof container, sterile)
Collection Instructions:
  Urine Cytology Only
  • Clean catch voided (preferred) or catheterized urine
  • A first morning voided specimen is not suitable.
  • Deliver specimen to the laboratory immediately.
  • Cells in urine degenerate rapidly and must be refrigerated within 2 hours of collection.
  Urine Cytology and Fish for Bladder Cancer
  • Clean catch voided
  • Collect in Thin Prep Urocyte urine collection kit container available from UMMC Specimen Management (612-273-5014). Note: Do not collect urine after cystoscopy to avoid lubricant contamination.
  Intraoperative washings/brushings of urinary bladder, urethra, ureters or renal pelvis
  • Catheterize ureters to pelvis for suspected renal or pelvic lesions or catheterize ureter to a point just below the level of suspected lesion. Always do the other ureter as a control.
  • Washing: Using standard cystoscopy technique, obtain washing specimens, carefully denoting specific specimen sites for each specimen on the test request form.
  •  Brushing: Using standard cystoscopy technique, identify the lesion in question and obtain a brushing sample of the lesion.
  •  Label right and left ureteral specimens.
  • Deliver specimen to the laboratory immediately.
  Submit the specimen fresh to the Cytology Laboratory along with the complete Cytology test request form. If transport of the specimen will be delayed more than 24 hours, add an equal volume of 50% ethyl alcohol. If transport time will be less than 24 hours, or fixative is not available, the specimen should be refrigerated until transport to the lab.  
Patient Preparation:Hydrate patient (see collection instructions).
Causes for Rejection:Undue delay in transport; specimens delivered on weekends or after 1600 must contain at least 50% alcohol fixative (exception: ureteral or ureteral brushing specimens will be processed, but may be suboptimal)


Processing and Shipping

Specimen Processing:Specimen must be processed ASAP. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature. Must arrive within 2 hours of collection. Must arrive Mon-Fri, 0800-1530 if no fixative added. If collected after hours, add an equal amount of at least 50% ETOH and refrigerate until delivery of specimen. Record on the specimen container that fixative has been added.
Test Performed at or Referral Lab Cytology  (UMMC-East Bank, Fairview Ridges - FRH, Fairview Southdale - FSH, UMMC/UMMCH-West Bank)


Interpretive

Reference Range:Reported as negative to positive for malignant cells.
Use:Establish the presence of primary or metastatic neoplasms, cytomegalic inclusion disease; aid in the diagnosis of infections with herpesvirus, Blastomyces, cytomegalovirus and Schistosoma; malacoplakia; hemolytic anemia - renal hemosiderosis.


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