Cytology, Urinary Tract


Sunquest Code:NGNCTCoPath Code:NGYN
Epic Code:LAB4600Epic Name:Cytology Non Gyn
Sunquest Code (non-Epic sites):COPATH  
Synonyms:Urine Cytology; Decoy Cells; Voided Urine; Catheterized Urine; Urinary Bladder Washing; Urethra Washing; Ureter Washing; Renal Pelvis Washing
Methodology:Preparation, staining and microscopic evaluation
Turnaround Time:Performed Mon-Fri, 0800-1500; results are reported within 1-2 days.
Special Instructions:Provide pertinent clinical history.


Collection Instructions

Specimen:Voided urine, catheterized urine, bladder washing, ureter washing, and renal pelvic washing
Optimal Volume:10 mL or more (Cytology NGNCT only) and 35  mL or more (Cytology NGNCT with FISH)
Container:Plastic leakproof container, sterile (ThinPrep UroCyte urine collection kit)
Collection Instructions:
Use ThinPrep Urocyte urine collection kit only if NGNCT order states "Urine Cytology with FISH".

Urine Cytology NGNCT Only:
  • Add an equal amount of 50-100% ranged ETOH (If ETOH is not available, specimen must be received in lab during business hours, Mon-Fri 0800-1500). Record on the specmen container that fixative has been added.
  • Clean catch voided (preferred) or catheterized urine
  • A first morning voided speicmen is not suitable.
  • For ureteral specimens, always sample both ureters so other ureter can be used as a control.


Urine Cytology NGNCT with FISH:
  • Clean catch voided, catheterized urine, bladder oand ureter washings ONLY.
  • It's recommended that at least 35 mL of urine is collected to ensure adequate sampling.  If a urine sample is 35 mL or less, Cytology order (NGNCT) will be cancelled, and FISH order will be performed only (FISHCT).  Submission of a suboptimal volume (less than 35 mL) may result in insufficient cellular material required to render a diagnosis.
  • Collect in Thin Prep Urocyte urine collection kit container available from UMMC Client Services (612-273-7838). Note: Do not collect urine after cytoscopy to avoid lubricant contamination.


Intraoperative washings/brushings of urinarly bladder, urethra, ureters or renal pelvis:
  • Add an equal amount of 50-100% ranged ETOH (If ETOH is not available, specimen must be received in lab during business hours, Mon-Fri 0800-1500). Record on the specmen container that fixative has been added.
  • Always sample both ureters so other ureter can be used as a control.
Causes for Rejection:Undue delay in transport; incorrect fixative used (exception: ureteral or ureteral brushing specimens will be processed, but may be suboptimal).


Processing and Shipping

Specimen Processing:Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Specimen must be processed ASAP. Store in refrigerator.
Test Performed at or Referral Lab Cytology  (UMMC-East Bank, Fairview Ridges - FRH, Fairview Southdale - FSH, UMMC/UMMCH-West Bank)


Interpretive

Reference Range:Reported as negative to positive for malignant cells.
Use:Establish the presence of primary or metastatic neoplasms, cytomegalic inclusion disease; aid in the diagnosis of infections with herpesvirus, Blastomyces, cytomegalovirus and Schistosoma; malacoplakia; hemolytic anemia - renal hemosiderosis.


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