Imipramine and Desipramine


Sunquest Code:IMIPRM  
Epic Code:LAB684Epic Name:Imipramine Level
Synonyms:Tofranil
Methodology:Liquid chromatography/Tandem mass spectrometry
CPT Code:80335
Test Includes:Imipramine, Desipramine (metabolite)
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 3 days.
Compliance:

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:0.7 mL
Container:Red (no gel) (Green (lithium heparin, no gel), Green (sodium heparin, no gel))
Collection Instructions:With patient at steady-state, collect sample immediately prior to next dose (trough). Steady-state is achieved after 2.5-11 days of chronic oral dosing. Peak levels usually occur 2-6 hours after oral dose.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 2 mL, 0.24 mL minimum. Store at room temperature up to 3 days. Alternatively refrigerate or freeze.
Shipping Instructions:Ship at room temperature.
Test Performed at or Referral Lab Lab Sendouts  (MedTox)
Referral Lab number:59


Interpretive

Critical Range:Imipramine + Metabolite: 500 ng/mL; Desipramine: 500 ng/mL
Reference Range:Total (sum of imipramine and desipramine): 175-300 ng/mL; Desipramine: 100-300 ng/mL
Use:Therapeutic monitoring and assess toxicity.


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