Mephenytoin and Normephenytoin


Sunquest Code:MEPHEN  
Epic Code:LAB3608Epic Name:Mephenytoin and Normephenytoin
Synonyms:Mesantoin; Nirvanol
Methodology:High performance liquid chromatography with ultraviolet detection
CPT Code:80185 x2
Test Includes:Mephenytoin and Nirvanol (metabolite)
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 3 days.
Compliance:

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:1.4 mL
Container:Red (no gel) (Green (lithium heparin, no gel), Green (sodium heparin, no gel))
Collection Instructions:Usual sampling time is immediately prior to next dose (trough).
Contraindications:Use is contraindicated in patients who have shown a previous hypersensitivity to hydantoin products.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 2 mL, 0.6 mL minimum. Store at room temperature.
Shipping Instructions:Ship at room temperature.
Test Performed at or Referral Lab Lab Sendouts  (MedTox)
Referral Lab number:68


Interpretive

Critical Range:Mephenytoin: 20 ug/mL or greater
Reference Range:Mephenytoin: 1-5 ug/mL; Normephenytoin: 15-35 ug/mL.
Use:Therapeutic monitoring and assess toxicity.


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