Theophylline


Sunquest Code:THEO  
Epic Code:LAB35Epic Name:Theophylline Level
Synonyms:Aminophylline; Somophylline; Theo-Dur; Theolair; Theospan
Methodology:Turbidimetric rate
CPT Code:80198
Turnaround Time:Southdale and UMMC-West are performed and reported 24 hours/day; other sites are reported daily. Turnaround time is 2 hours for ER and stat requests. UMMC-East samples are sent to UMMC-West for testing.


Collection Instructions

Specimen:Blood
Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Container:Green (lithium heparin, gel) (Green (lithium heparin) on ICE, Red (no gel), Red or gold (gel))
Collection Instructions:Trough level is preferred; collect immediately prior to dose. Optimal sampling time for a peak level after oral dosage is 1-2 hours for fast release preparation and 4-6 hours post dose for slow release preparation. Optimal re-sampling time after change in dosage is 24-48 hours. Optimal sampling time for intravenous infusion is prior to infusion, 30 minutes after completion of loading dose, 4-6 hours after beginning thearpy, 12-18 hours after beginning therapy and then repeat as necessary to evaluate therapy.
Patient Preparation:Intake of caffeine should be avoided because caffeine is metabolized to theophylline.


Processing and Shipping

Specimen Processing:Centrifuge and transfer serum/plasma within 2 hours of collection. Aliquot 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Chemistry  (Fairview Range - FRMC, Fairview Southdale - FSH, UMMC/UMMCH-West Bank)


Interpretive

Critical Range:Geater than 25 mg/L
Therapeutic Range:10-20 mg/L; for apnea of prematurity (gestational age less than 38 weeks) = 6-14 mg/L
Use:Monitor therapeutic dosing and evaluate toxicity. Half-life is 3-8 h (adult); 1-8 h (child), and 12-60 h (neonate).


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