F-Actin (Smooth Muscle) Antibody, IgG with Reflex to Titer


Sunquest Code:FACTIN  
Epic Code:LAB3459Epic Name:F Actin EIA with Reflex
Synonyms:Smooth Muscle Antibody; F Actin
Methodology:Enzyme-linked immunosorbent assay (ELISA)/Indirect fluorescent antibody
CPT Code:83516, 86256
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-5 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.7 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Plasma. Lipemic or hemolyzed specimens.


Processing and Shipping

Specimen Processing:Centrifuge ASAP and aliquot 1 mL, 0.25 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:51174


Interpretive

Reference Range:

 

F-Actin (Smooth Muscle) Antibody, IgG

19 Units or less

Negative.

20-30 Units

Weak Positive. Suggest repeat testing in 2-3 weeks with fresh specimen.

31 Units or greater

Positive. Suggestive of autoimmune hepatitis or chronic active hepatitis.

 

Smooth Muscle Antibody, IgG Titer

< 1:20

Normal. No antibody detected

1:20-1:80

Weak Positive. Suggest repeat testing in 2-3 weeks with fresh specimen.

1:160 or greater

Positive. Suggestive of autoimmune hepatitis or chronic active hepatitis.

 

Note: In viral hepatitis, the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

 



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