Histoplasma capsulatum Antigen, Blood


Sunquest Code:HISTOP  
Epic Code:LAB3531Epic Name:Histoplasma Agn Blood
Order Instructions:See HISTPU for non-blood specimens.
Methodology:Enzyme immunoassay
CPT Code:87385
Turnaround Time:Specimens are sent to reference laboratory Mon-Thur; results are reported in 2-3 days.
Special Instructions:Patients should not have more than one serum histoplasma per 24 hours.


Collection Instructions

Specimen:Blood
Optimal Volume:4 mL blood
Minimum\Peds Volume:2.2 mL blood
Container:Red (no gel) (Purple (EDTA), Red or gold (gel))


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 2 mL, 1 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (MiraVista Diagnostics)
Referral Lab number:310


Interpretive

Reference Range:By report.
Limitations:Heterophile antibodies and rheumatoid factor can cause positive interference. Cross reactions due to closely related antigenic epitopes are seen in patients with blastomycosis, paracoccidiodomycosis and penicilliosis.
Use:Aid in the diagnosis of histoplasmosis by antigen detection. Measurement of antigen in urine offers the highest sensitivity for diagnosis of acute pulmonary or disseminated histoplasmosis. Testing bronchoalveolar lavage may improve the sensitivity for diagnosis of pulmonary histoplasmosis and CSF for diagnosis of meningitis. For monitoring therapy, testing both urine and serum offers the highest sensitivity.


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