Vitamin C, Plasma


Sunquest Code:VITC  
Epic Code:LAB4583Epic Name:Vitamin C
Synonyms:Ascorbic Acid
Methodology:High performance liquid chromatography
CPT Code:82180
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-6 days.


Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.8 mL
Collection Instructions:Place specimen on ice immediately after collection and protect samples from light.
Patient Preparation:Fasting specimens preferred
Causes for Rejection:Nonfrozen samples. EDTA plasma, whole blood or body fluids. Grossly hemolyzed specimens. Samples not protected from light.


Processing and Shipping

Specimen Processing:Centrifuge ASAP and aliquot 0.5 mL, 0.3 mL minimum into a light protected tube. Each vitamin level requested requires a separate aliquot tube.
Shipping Instructions:Ship on dry ice. Protect from light.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80380


Interpretive

Reference Range:23-114 umol/L Vitamin C concentrations lower than 11 umol/L indicates deficiency. Vitamin C concentrations between 11-23 umol/L are consistent with moderate risk of deficiency due to inadequate tissue storage.
Use:Prolonged vitamin C (L-ascorbic acid) deficiency results in scurvy, which is confirmed by concentrations of less than11 umol/L. Excessive ("megadose") vitamin C intake is generally believed to be nontoxic, but may lead to nephrolithiasis (calcium oxalate), uricosuria and increased iron absorption.


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