GM-1 Antibody Panel


Sunquest Code:GM1PAN  
Epic Code:LAB3508Epic Name:GM1 Antibody Panel
Synonyms:GM1; Ganglioside-monosialic Acid Antibody; GM 1 Antibody Panel; GM1 Antibody Panel
Methodology:Enzyme-linked immunosorbent assay
CPT Code:83516 x2
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:0.6 mL
Minimum\Peds Volume:0.4 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Severely lipemic, hemolyzed or icteric specimens, plasma, CSF or other body fluids. Room temperature specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 0.3 mL, 0.1 mL minimum within 2 hours of collection. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50591 (GM1 PAN)


Interpretive

Reference Range:

GM1 Ab IgG

29 IV or less: Negative

30-50 IV: Equivocal

51-100 IV: Positive

101 IV or greater: Strong positive

GM1 Ab IgM

29 IV or less: Negative

30-50 IV: Equivocal

51-100 IV: Positive

101 IV or greater: Strong positive

 

 

Use:Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.


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