Multiple Sclerosis Panel - LG2771


Sunquest Code:Indiv Codes  
Epic Code:LAB4909Epic Name:Send Outs Misc Test
Order Instructions:Order both OLIGO and MBPAN
Synonyms:Protein Electrophoresis, CSF; CELP; ELP, Cerebrospinal Fluid; Oligoclonal Band Profile
Methodology:Refer to individual test listings
Test Includes:Immunoglobulin G, CSF; IgG synthesis rate, CSF; IgG index; myelin basic protein, CSF; albumin, serum by nephelometry; albumin, CSF; albumin, index; Immunoglobulin G, serum; CSF IgG/Albumin Ratio, CSF Oligoclonal Bands
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.


Collection Instructions

Specimen:Blood and CSF
Optimal Volume:2 mL CSF and 2 mL blood
Minimum\Peds Volume:1.5 mL CSF and 1.2 mL blood
Container:Red (no gel) (Sterile tube, Red or gold (gel))
Collection Instructions:Collect CSF specimen in a sterile container, collect blood specimen in a red/black top (gel) tube. Blood specimen must be collected within 48 hours of CSF. Specimens need to be assayed together for interpretation.
Causes for Rejection:Hemolysis is associated with falsely elevated levels of MBP in the CSF.


Processing and Shipping

Specimen Processing:Send serum, collected within 2 days of CSF, with the CSF specimen. Centrifuge at room temperature. CSF: aliquot 2 mL, 1.5 mL minimum; serum: 1 mL, 0.5 mL minimum. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing. Store in freezer.
Shipping Instructions:Ship on dry ice.
Stability:C&P order both OLIGO and MBPAN. If all available CSF is bloody, centrifuge the sample and separate from cells prior to freezing.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80440 (OLIGO) and 80515 (MBP)


Interpretive

Reference Range:

IgG, Serum

Age

mg/dL

 

Age

mg/dL

0-30 d

611-1542

 

1 y

331-1164

1 mo

241-870

 

2 y

407-1009

2 mo

198-577

 

3 y

423-1090

3 mo

169-558

 

4 y

444-1187

4 mo

188-536

 

5-7 y

608-1229

5 mo

165-781

 

8-9 y

584-1509

6 mo

206-676

 

10 y and older

768-1632

7-8 mo

208-868

 

 

 

9-11 mo

282-1026

 

 

 

 

IgG, CSF

0-6.0 mg/dL

Albumin, Serum (NEPH)

3500-5200 mg/dL

Albumin, CSF

0-35 mg/dL

Albumin Index

0.0-9.0

CSF, IgG Synthesis Rate

0.0-8.0 mg/d

IgG Index

0.28-0.66

CSF, IgG/Albumin Ratio

0.09-0.25

CSF Oligoclonal Bands #

0-1 Bands

Myelin Basic Protein

0.00-1.10 ng/mL

Interpretation

By report

*For additional information refer to individual test.

A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum.

 

Use:Diagnosis of diseases of the central nervous system including meningitis, tumor, syphilis, and multiple sclerosis.


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