Multiple Sclerosis Panel - LG2771


Sunquest Code:Indiv Codes  
Epic Code:LAB4909Epic Name:Send Outs Misc Test
Order Instructions:Order both OLIGO and MBPAN
Synonyms:Protein Electrophoresis, CSF; CELP; ELP, Cerebrospinal Fluid; Oligoclonal Band Profile
Methodology:Refer to individual test listings
CPT Code:83873, 83916, 82784 x4, 82040, 82042, 82784
Test Includes:Immunoglobulin G, CSF; IgG synthesis rate, CSF; IgG index; myelin basic protein, CSF; albumin, serum by nephelometry; albumin, CSF; albumin, index; Immunoglobulin G, serum; CSF IgG/Albumin Ratio, CSF Oligoclonal Bands
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.


Collection Instructions

Specimen:Blood and CSF
Optimal Volume:2 mL CSF and 2 mL blood
Minimum\Peds Volume:1.5 mL CSF and 1.2 mL blood
Container:Red (no gel) (Sterile tube, Red or gold (gel))
Collection Instructions:Collect CSF specimen in a sterile container, collect blood specimen in a red/black top (gel) tube. Blood specimen must be collected within 48 hours of CSF. Specimens need to be assayed together for interpretation.
Causes for Rejection:Hemolysis is associated with falsely elevated levels of MBP in the CSF.


Processing and Shipping

Specimen Processing:Send serum, collected within 2 days of CSF, with the CSF specimen. Centrifuge at room temperature. CSF: aliquot 2 mL, 1.5 mL minimum; serum: 1 mL, 0.5 mL minimum. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing. Store in freezer.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80440 (OLIGO) and 80515 (MBP)


Interpretive

Reference Range:

IgG, Serum

Age

mg/dL

 

Age

mg/dL

0-30 d

611-1542

 

1 y

331-1164

1 mo

241-870

 

2 y

407-1009

2 mo

198-577

 

3 y

423-1090

3 mo

169-558

 

4 y

444-1187

4 mo

188-536

 

5-7 y

608-1229

5 mo

165-781

 

8-9 y

584-1509

6 mo

206-676

 

10 y and older

768-1632

7-8 mo

208-868

 

 

 

9-11 mo

282-1026

 

 

 

 

IgG, CSF

0-6.0 mg/dL

Albumin, Serum (NEPH)

3500-5200 mg/dL

Albumin, CSF

0-35 mg/dL

Albumin Index

0.0-9.0

CSF, IgG Synthesis Rate

0.0-8.0 mg/d

IgG Index

0.28-0.66

CSF, IgG/Albumin Ratio

0.09-0.25

CSF Oligoclonal Bands #

0-1 Bands

Myelin Basic Protein

0.00-1.10 ng/mL

Interpretation

By report

*For additional information refer to individual test.

A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum.

 

Use:Diagnosis of diseases of the central nervous system including meningitis, tumor, syphilis, and multiple sclerosis.


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