N-Telopeptide, Cross-Linked, Urine


Sunquest Code:UNTELU  
Epic Code:LAB3848Epic Name:N Telopeptide, Cross-Linked Urine
Synonyms:NTx; Crosslinked N-telopeptide of Type 1 Collagen; N Telopeptide Crosslinked
Methodology:Chemiluminescent immunoassay
CPT Code:82523
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Special Instructions:For monitoring therapy, a baseline sample should be collected prior to initiation of therapy. Subsequent samples for comparison should be collected at the same time of day as the baseline sample.
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Urine Collection Procedure



Collection Instructions

Specimen:Urine, second morning void (preferred) or timed
Optimal Volume:Submit entire collection; analysis requires 0.5 mL
Container:Plastic leakproof container, sterile (3 L plastic jug)
Collection Instructions:Refrigerate during collection, Collect without preservative.
Causes for Rejection:Collected with preservative, contaminated with blood, hemolyzed.


Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Aliquot 1 mL, 0.5 mL minimum.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:70062 (NTX)


Interpretive

Reference Range:

Age

Male

nM BCE/mM creatinine

Female

nM BCE/mM creatinine

7-9 y

167-578

201-626

10-12 y

152-505

173-728

13-15 y

103-776

38-515

16-17 y

34-313

20-144

18 y and older

21-83

 

Premenopausal

 

17-94

Postmenopausal

 

26-124

A decrease of 30-40% from the NTx baseline after 3 months of therapy is a typical response to anti-resorptive therapy.

A reference range for children under 7 years of age is not provided by the reference laboratory.

 

Use:Estimation of bone resorption.


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