Coccidioides Antibody by CF


Sunquest Code:CIAB  
Epic Code:LAB3379Epic Name:Coccidioides Antibody
Synonyms:Fungal Antibody, Coccidioides; Fungus; San Joaquin Fever; Valley Fever
Methodology:Complement fixation
CPT Code:86635
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-3 days.
Special Instructions:Parallel testing is preferred. Label samples as acute or convalescent. Convalescent sample must be sent within 30 days of acute sample.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.5 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Hemolyzed, icteric or lipemic specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot ASAP or within 2 hours of collection, 1 mL, 0.15 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50170


Interpretive

Reference Range:Less than 1:2 titer Any titer suggests past or current infection. However, greater than 30% of cases with chronic residual pulmonary disease have negative Compliment Fixation tests. Titers of less than 1:32 may indicate past infection or self-limited disease; anticoccidiodal CF antibody titers in excess of 1:16 may indicate disseminated infection , CF serology may be used to follow therapy.
Use:CF measures both IgM and IgG. As single antibody titers are generally not diagnostic, paired samples are preferred. Acute and convalescent samples (drawn at least 21 days apart) showing at least a four-fold rise in titer, are diagnostic.


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