Serotonin, Serum


Sunquest Code:SERO  
Epic Code:LAB121Epic Name:SEROTONIN
Methodology:High performance liquid chromatography
CPT Code:84260
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel) (Red (no gel))
Patient Preparation:Abstain from medications for 72 hours prior to collection.
Causes for Rejection:Specimens other than serum, nonfrozen samples.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 1 hour of collection 1 mL, 0.3 mL minimum. Freeze immediately.
Shipping Instructions:Critical frozen. Separate specimens must be submitted when multiple tests are ordered.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80397


Interpretive

Reference Range:50-220 ng/mL
Limitations:In general, EDTA whole blood (as compared to serum) preserved with ascorbic acid will give values most representative of blood concentrations. Most (95%) blood serotonin is found in platelets - refer to Serotonin, Whole Blood.
Use:Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.


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