Leukocyte Adhesion Deficiency - LG3033


Sunquest Code:ARMISC  
Epic Code:LAB4909Epic Name:Send Outs Misc Test
Synonyms:FLOLAD; LAD; Beta 2 Integrins
Methodology:Flow cytometry
CPT Code:86356 x3
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 1-3 days.
Special Instructions:Sample must be assayed within 48 hours of collection. Results of a CBC and differential, including an eosinophil and basophil count, must be sent with the whole blood specimen.


Collection Instructions

Specimen:Blood
Optimal Volume:5 mL
Minimum\Peds Volume:1 mL
Causes for Rejection:Clotted, room temperature or frozen specimens. Specimen received >48 hours after collection.


Processing and Shipping

Specimen Processing:Do not process.
Shipping Instructions:Ship overnight at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2004359


Interpretive

Reference Range:

Granulocytes

% positive

CD11b

93-100

CD15

91-100

CD18

98-100

 

 

Use:The Leukocyte Adhesion Deficiency Panel measures the receptors CD111b, CD15 and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.


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