Immune Complex Panel


Sunquest Code:ICP  
Epic Code:LAB3558Epic Name:Immune Complex Panel
Synonyms:C1Q Binding Assay; Raji Cell Immune Complex Assay
Methodology:Enzyme-linked immunosorbent assay; flow cytometry
CPT Code:86332 x2
Test Includes:C1Q binding and Raji cell immune complex assays.
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 2-9 days.
Compliance:

Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Red (no gel) (Red or gold (gel))
Causes for Rejection:Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles.


Processing and Shipping

Specimen Processing:Allow sample to clot (up to 1 hour) then separate within 30 minutes. Transfer serum into two 1 mL aliquots, 0.5 mL minimum per aliquot. Keep samples together. Separate samples must be sent for each test.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50667


Interpretive

Reference Range:

C1Q Binding Assay

Less than 4 µgE/mL is considered negative for circulating complement binding immune complexes.

Raji Cell Immune Complex Assay

By report.

 Immune complexes bind to Raji Cells via their complement receptors. The immunoglobulin portion of the immune complex is then detected by flow cytometry with anti-human IgG-FITC.

 

Use:Many autoimmune disorders, chronic infections and malignancies are associated with circulating immune complexes. Quantitation of immune complexes assists in staging immunologic disorders.


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