Immune Complex Panel


Sunquest Code:ICP  
Epic Code:LAB3558Epic Name:Immune Complex Panel
Synonyms:C1Q Binding Assay; Raji Cell Immune Complex Assay
Methodology:Enzyme-linked immunosorbent assay; flow cytometry
Test Includes:C1Q binding and Raji cell immune complex assays.
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 2-9 days.
Compliance:

Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Red (no gel) (Red or gold (gel))
Causes for Rejection:Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles.


Processing and Shipping

Specimen Processing:Allow sample to clot (up to 1 hour) then separate within 30 minutes. Transfer serum into two 1 mL aliquots, 0.5 mL minimum per aliquot. Keep samples together and freeze immediately. Separate specimens must be sent when multiple tests are ordered.
Shipping Instructions:Ship on dry ice.
Stability:Specimen is stable for 2 weeks frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50667


Interpretive

Reference Range:
C1Q Binding Assay Less than or equal to 3.9 μg Eq/mL is considered negative for circulating complement binding immune complexes. Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate the immune complex in a disease process.
Raji Cell Immune Complex Assay By report
Immune complexes bind to Raji Cells via their complement receptors. The immunogloculin portion of the immune complex is then detected by flow cytometry with anti-human IgG-FITC.
Use:Many autoimmune disorders, chronic infections and malignancies are associated with circulating immune complexes. Quantitation of immune complexes assists in staging immunologic disorders.


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