Myoglobin, Urine, Quantitative


Sunquest Code:UMY  
Epic Code:LAB3846Epic Name:Myoglobin Quantitative Urine
Synonyms:Rhabdomyolysis; Myoglobinuria
Methodology:Electrochemiluminescence immunoassay
CPT Code:----------CPTCODES HERE----------
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1 day.
Special Instructions:
To facilitate more rapid patient diagnosis, the following protocol is recommended for evluation of patients with suspected rhabdomyolysis and myoglobinuria.
  1. C&P staff order UMY.
  2. CC1 staff order UBLD; perform even when urine is clear.
  3. If speicmen is positive for blood; CC1 staff order (credit in GenLab) CK on closest (timing) plasma (serum also acceptable in this case) available for this patient; ideally this sample should be collected within 2-6 hours.
  4. If blood (urine) is positive and CK (plasma) is elevated; send plasma to Fairview Southdale for a plasma myoglobin (credit in GenLab).
  5. Call results to physician to determine whether urine myoglobin testing is still desired.
  6. Refer questions to the Clinical Chemistry resident (pager: 612-899-1483.)

 
Causes of
Red Urine
Hematuria (red
cells in urine)
Hemoglobinuria Myoglobinuria and
Rhabdomyolysis
Reagent Strip-bld,ur Positive Positive Positive
Appearance, urine Cloudy red Clear/red brn Clear/red brn
Sediment, urine RBC present RBC absent RBC absent
Appearance, plasma   Normal, hemolyzed Normal
CK Total, plasma   Normal, sl elevation Marked elevation
Myoglobin, plasma   Normal Marked elevation
In the majority of cases, the testing scheme outlined above will answer the clinical question in evaluating patients with suspected rhabdomyolysis.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Associated Links:

Urine Collection Procedure



Collection Instructions

Specimen:Urine, random collection or 24 hour collection
Optimal Volume:1 mL
Minimum\Peds Volume:0.5 mL
Container:3 L plastic jug (Plastic leakproof container, sterile)
Collection Instructions:Refrigerate during collection.


Processing and Shipping

Specimen Processing:

Aliquot 1 mL, 0.5 mL minimum. Adjust pH to 8.0-9.0 by adding 10% Na2CO3 (sodium carbonate). Alternatively aliquot 4 mL urine, 0.5 mL minimum, into an ARUP Standard Transport Tube prefilled with Sodium Carbonate. Record time and volume on container. Store in freezer.

 

Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:20223


Interpretive

Reference Range:0-1 mg/L Patients with urine myoglobin greater than 15 mg/L are at risk of acute renal failure. Results between 1 and 15 mg/L are associated with vigorous exercise, myocardial infarct, mild muscle injury and other conditions.


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