PSA Total and Free


Sunquest Code:FPSA  
Epic Code:LAB171Epic Name:PSA Total and Free
Synonyms:FPSA; Prostatic Specific Antigen
Methodology:Electrochemiluminescence immunoassay
CPT Code:84153, 84154
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel))
Causes for Rejection:Grossly hemolyzed samples.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection, 1 mL, 0.5 mL minimum. Store in freezer.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80206 (PSA FP)


Interpretive

Reference Range:

By report. Results include PSA-Free, PSA, PSA-Percent Free.

 

The Roche Modular E170PSA method is used. Results obtained with different assay methods or kits cannot be used interchangeably. The Roche Modular E170PSA method is approved for use as an aid in the detection of prostate cancer when used in conjunction with a digital rectal exam in men age 50 and older. The Roche Modular E170PSA method is also indicated for the serial measurement of PSA to aid in the prognosis and management of prostate cancer patients. Elevated PSA concentrations can only suggest the presence of prostate cancer until biopsy is performed. PSA concentrations can also be elevated in benign prostatic hyperplasia or inflammatory conditions of the prostate. PSA is generally not elevated in healthy men or men with non-prostatic carcinoma.

 

ARUP Roche Modular E170 Free PSA method in conjunction with the Roche Modular E170PSA method to determine the free PSA percentage. The free PSA percentage is an aid in distinguishing prostate cancer from benign prostatic conditions in men age 50 and older with a total PSA between 3 and 10 ng/mL and negative digital rectal examination findings. Prostatic biopsy is required for the diagnosis of cancer.

 

In patients with total PSA concentrations of 4-10 ng/mL, the probability of finding prostate cancer on needle biopsy by age in years:

% Free
PSA Ratio

 

50-59 y

 

60-69 y

 

70 y & Older

10% or less

49%

58%

65%

11-18%

27%

34%

41%

19-25%

18%

24%

30%

26% or greater

9%

12%

16%

Other factors may help determine the actual risk of prostate cancer in individual patients.

 



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