RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG


Sunquest Code:RNPIGG  
Epic Code:LAB6336Epic Name:RNP ANTIBODY IGG
Synonyms:ENA (RNP) Antibody; Extractable Nuclear Antigen Antibody; Ribonucleic Protein (ENA) Antibody; Anti-RNP (ENA) Antibody
Methodology:Multiplex flow immunoassay
CPT Code:----------CPTCODES HERE----------
Test Includes:RNPA and RNP68
Turnaround Time:Performed Mon-Fri; results reported the same day.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.9 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel))
Causes for Rejection:Severely lipemic or hemolyzed specimens.


Processing and Shipping

Specimen Processing:Centrifuge ASAP and aliquot 1 mL, 0.35 mL minimum. Store in refrigerator up to 7 days.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Specialty Core  (UMMC-East Bank)


Interpretive

Reference Range:

 

Negative

Less than 1.0 AI

Positive

1.0 AI or greater

Antibody index (AI) values reflect qualitative changes in antibody concentration that cannot be directly associated with clinical condition or disease state.

 

Use:RNP antibody is seen in 95-100% of mixed connective tissue disease and is considered specific for this syndrome if other antibodies are negative; RNP is also present in 20-30% of SLE and 15-25% of progressive system sclerosis. RNP antigens also contain epitopes which are immunologically identical to free Smith antigens. The Smith antibody response must be considered when interpreting RNP results.


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