Diphenhydramine


Sunquest Code:DIPHEN  
Epic Code:LAB3061Epic Name:Diphenhydramine Level
Synonyms:Benadryl
Methodology:Liquid chromatography/Tandem mass spectrometry
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 7 days.


Collection Instructions

Specimen:Blood
Optimal Volume:6 mL
Minimum\Peds Volume:1.4 mL
Container:Red (no gel) (Green (lithium heparin, no gel), Green (sodium heparin, no gel))
Collection Instructions:Trough levels are the most reproducible.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 3 mL, 0.6 mL minimum. Store at room temperature.
Shipping Instructions:Ship at room temperature.
Stability:Samples are stable up to 3 days at room temperature. For longer storage, refrigerate or freeze.
Test Performed at or Referral Lab Lab Sendouts  (MedTox)
Referral Lab number:40


Interpretive

Reference Range:30-50 ng/mL The stated reference range is the range where a significant antihistaminic effect is expected without significant sedation. When sedation is desired, the therapeutic range would be approximately 50-300 ng/mL.


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