Catecholamines, Plasma (Epinephrine & Norepinephrine) - LG3584


Sunquest Code:ARMISC  
Epic Code:LAB4909Epic Name:Send Outs Misc Test
Synonyms:Catecholamines, Free; Epinephrine/Norepinephrine, Plasma
Methodology:High performance liquid chromatography
CPT Code:82384
Test Includes:Epinephrine and Norepinephrine
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.


Collection Instructions

Specimen:Blood
Optimal Volume:8 mL
Minimum\Peds Volume:4.4 mL
Container:Green (sodium heparin, no gel) on ICE (Green (lithium heparin) on ICE)
Collection Instructions:Chill the collection tubes before drawing sample; avoid hemolysis. Place tubes on ice and send to laboratory immediately. Due to large specimen volume, the 9 mL green (sodium heparin, no gel) tube is preferred.
Patient Preparation:
Patient should be calm and in a supine position for 30 minutes prior to collection. Medications which may interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopalevodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, methyldopa (Aldomet), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclics and vasodialators. The effect of drugs on catecholamine results may not be predictable.    
Causes for Rejection:Not on ice, EDTA plasma, serum or urine specimens, ambient temperature.


Processing and Shipping

Specimen Processing:Separate plasma from cells within 1 hour. Centrifuge and aliquot 4 mL, 2.1 mL minimum. Freeze immediately.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80957


Interpretive

Reference Range:

 

Age

Epinephrine

pg/mL

Norepinephrine

pg/mL

2-10 d

36-400

170-1180

11 d – 3 mo

55-200

370-2080

4-11 mo

55-440

270-1120

1 y

36-640

68-1810

2 y

18-440

170-1470

3-17 y

18-460

85-1250

18 y and older

10-200

80-520

 

Small increases in catecholamines (less than 2 times the upper reference limit) usually are the result of physiological stimuli, drugs or improper specimen collection. Significant elevation of one or more catecholamines (2 or more times the upper reference limit) is associated with an increased probability of a neuroendorine tumor. Measurement of plasma or urine fractionated metanephrines provide better diagnostic sensitivity than measurement of catecholamines.

 

Medications which may interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopalevodopa (Sinemet), clonidine, dexmethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, labetalol, methyldopa (Aldomet), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol, reserpine, theophylline, tricyclic antidepressants and vasodilators. The effects of drugs on catecholamine results may not be predictable.

 

A reference range is not provided by reference laboratory for patients under 2 days of age.

 

Use:Refer to Catecholamines, Plasma (Epinephrine, Norepinephrine and Depamine).


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