Histamine, Plasma

Sunquest Code:HISTW  
Epic Code:LAB1033Epic Name:Histamine
Methodology:Enzyme-linked immunosorbent assay
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-6 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Purple (EDTA) (See Collection Instructions)
Collection Instructions:Collect in pre-chilled purple (EDTA) tube and place on ice. Deliver to lab within 10 minutes of collection.
Causes for Rejection:Nonfrozen, lipemic or hemolyzed specimens.

Processing and Shipping

Specimen Processing:Separate upper 2/3 of plasma within 20 minutes. Centrifuge and aliquot 1 mL, 0.5 mL minimum. Freeze immediately. CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Shipping Instructions:Ship on dry ice.
Stability:After separation from cells: 6 hours refrigerated, 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:70036


Reference Range:0-8 nmol/L

Histamine is one of the major mediators of allergic reactions. Thus, reasons to measure histamine in plasma or urine are often related to allergies. Some carcinoid tumors, particularly of gastric origin, produce and release excessive histamine. Urticaria pigmentosa, characterized by multiple, irregular, round or oval, yellowish brown to reddish brown macules and papules related to the presence of skin melanin overlying clusters of mast cells, can result in release of excessive histamine. Symptoms of flushing, itching, urticaria, vomiting, syncope, or shock are assumed to be due to histamine release, which coincides with increased urine or plasma levels. Systemic mastocytosis or basophilia can produce persistent elevations in plasma or urine histamine concentrations.


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