Porphyrins, Fractionation and Quantitation, Urine

Sunquest Code:PORPU  
Epic Code:LAB6057Epic Name:Porphyrins, Quantitative Urine
Synonyms:Uroporphyrins, Urine; Porphyrins, Total Urinary
Methodology:High performance liquid chromatography
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-5 days.
Special Instructions:Total volume and collection time interval is required. Protect specimen from light during collection, processing and shipping.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

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Urine Collection Procedure

Collection Instructions

Specimen:Urine, random or timed collection, protected from light
Optimal Volume:Submit entire collection; analysis requires 2 mL
Container:Plastic leakproof container, sterile (3 L plastic jug)
Collection Instructions:Protect sample from light and refrigerate during collection. 24 hour collection preferred.
Causes for Rejection:Not protected from light; stored at room temperature. Body fluids other than urine.

Processing and Shipping

Specimen Processing:Aliquot 4 mL, 2 mL minimum. Protect from light. Store in freezer. Record total volume and collection time interval on transport tube.
Shipping Instructions:Ship on dry ice.
Stability:4 days at refrigerated temperature, 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2002058


Reference Range:
Component μmol/mol crt
Urophorphyrin 0-4
Heptacarboxylate Porphyrin 0-2
Coproporphyrin I 0-6
Coproporphyrin III 0-14
Use:Urine prophyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias such as acute intermittent porphyria (AIP) requires urine porphobilinogen (PBG) testing.

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