Histone Antibody, IgG


Sunquest Code:HSTON  
Epic Code:LAB3548Epic Name:HISTONE ANTIBODY IGG
Synonyms:Anti-histone Antibody IgG; Drug Induced SLE
Methodology:Enzyme-linked immunosorbent assay
CPT Code:83516
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.


Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Grossly hemolyzed, icteric or lipemic specimens. Plasma or urine.


Processing and Shipping

Specimen Processing:Separate serum from cells ASAP. Centrifuge and aliquot 0.5 mL, 0.3 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50860 (AHA)


Interpretive

Reference Range:

None detected

Less than 1.0 Units

Inconclusive

1.0-1.5 Units

Positive

1.6-2.5 Units

Strong positive

Greater than 2.5 Units

 

 

Use:Histone antibodies are present in 20-55% of idiopathic SLE and 80-95% of drug induced SLE. They occur in less than 20% of other types of connective tissue diseases.


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