Parvovirus B19 Antibody, IgM


Sunquest Code:PARVM  
Epic Code:LAB6039Epic Name:Parvovirus B19 Antibody, IgM
Methodology:Enzyme-linked immunosorbent assay
CPT Code:86747
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported in 1-3 days.
Special Instructions:Parallel testing is preferred. Label samples as acute or convalescent. Convalescent specimens must be received within 30 days from receipt of the acute specimens.


Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel))
Causes for Rejection:Lipemic, icteric, hemolyzed or heat-inactivated specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 0.5 mL, 0.3 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:65122 (PARVO M)


Interpretive

Reference Range:

0.89 IV or less

Negative: No significant level of detectable Parvovirus B19 IgM antibody.

0.90-1.10 IV

Equivocal: Repeat testing in 10-14 days may be helpful

1.11 IV or greater

Positive: IgM antibody to Parvovirus B19 detected which may indicate a current recent infection.

However, low levels of IgM antibody may occasionally persist for more than 12 months post-infection.

The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.

 

Appearance of an IgM antibody response normally occurs 7-14 days after the onset of diseases. Testing immediately post-exposure is of no value without a later convalescent specimen.

 

A residual IgM response may be distinguished from early IgM response to infection by testing sera from patients 3-4 weeks later for changing levels of specific IgM antibodies.

 

Immunocompromised patients may have a delayed or absent antibody response. Therefore, antibody levels may not be the optimal way to diagnose parvovirus infection in these patients. The best method in these situations is detection of parvovirus DNA in serum.

 



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