Platelet Function Closure Time with Reflex to ADP


Sunquest Code:PFCT  
Epic Code:LAB3672Epic Name:Platelet Function Closure with Reflex
Synonyms:Replaces Bleeding Time; Recommended for Aspirin Resistance
Methodology:Activated clotting
CPT Code:----------CPTCODES HERE----------
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:

Do not send in PTS.

 



Collection Instructions

Specimen:Blood
Optimal Volume:5.4 mL (in two 3 mL tubes for correct anticoagulant to blood ratio)
Minimum\Peds Volume:2.7 mL (in a 3 mL tube) Note: This volume does not permit further testing if results are abnormal.
Collection Instructions:

Samples should be collected using a 21 gauge needle or larger. Do not use first 2 mL of blood collected. For correct anticoagulant to blood ratio place 2.7 mL blood in 3 mL tube. If patient's hematocrit is greater than 55%, contact laboratory to obtain a special tube. Do not send in Pneumatic Tube System (PTS).

 

After Care:If the patient has a coagulation abnormality, apply direct pressure to the puncture site for 10 minutes; apply a pressure dressing. Instruct the patient to leave the bandage on for 12 hours.
Causes for Rejection:Over filled or under filled tubes; clotted specimens; plasma specimens; centrifuged specimens; hemolyzed specimens; refrigerated specimens; specimens greater than 4 hours; specimens sent through the PTS.


Processing and Shipping

Specimen Processing:Do not process. Do not store.
Shipping Instructions:

Ship at room temperature. Specimens must arrive ASAP (within 3 hours if possible) as testing must be completed within 4 hours of collection. Do not send in PTS.

 

Test Performed at or Referral Lab Coagulation  (Fairview Range - FRMC, UMMC-East Bank, Fairview Ridges - FRH, Fairview Southdale - FSH, UMMC/UMMCH-West Bank, Fairview Clinics)


Interpretive

Reference Range:

The collagen/epinephrine (CEPI) membrane detects platelet dysfunction induced by any intrinsic platelet defects (von Willebrand disease, aspirin, etc). Abnormal samples (CEPI greater than 170) are tested as a second step on the collagen/ADP (CADP) membrane to enable discrimination of aspirin effects.

 

 

Col/EPI

Col/ADP

Normal

Less than 170 s

Less than 120 s

Aspirin

abnormal

normal

von Willebrand Disease

abnormal

abnormal

Glanzmann’s Thrombasthenia

abnormal

abnormal

Closure times may be prolonged with platelet counts less than 150,000 µL or hematocrit less than 35%.

 

Use: Closure time is indicated when a disorder of platelet function is suspected by a personal or family history of easy bruising, nosebleeds, menorrhagia or post-operative bleeding. It is not recommended as a screen for potential bleeding risk. Abnormal closure times, indicating possible defective platelet function, should be further investigated with standard platelet aggregation tests. The platelet function closure time (CT) replaced bleeding time which was a poor indicator of surgical bleeding risk, labor intensive and operator dependent, demonstrated poor correlation to platelet function, and caused scarring. The CT is sensitive to platelet adhesion and aggregation abnormalities, thereby providing increased sensitivity for von Willebrand screening and aspirin-induced platelet dysfunction in comparison to the bleeding time.


Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
systemlabguide@fairview.org for TestID: 3811"