CRP Cardiac Risk


Sunquest Code:CRPC  
Epic Code:LAB150Epic Name:CRP Cardiac Risk
Synonyms:Cardiac Reactive Protein; CRPC; C-Reactive Protein; C Reactive Protein; CRP, High Sensitivity
Methodology:Nephelometry
Turnaround Time:Performed and reported 24 hours/day.


Collection Instructions

Specimen:Blood
Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Container:Green (lithium heparin, gel) (Red (no gel), Red or gold (gel))
Causes for Rejection:Samples not separated from cells within 2 hours of collection.
Contraindications:Do not order this test for indicator of inflammation; order C-Reactive Protein, Inflammation.


Processing and Shipping

Specimen Processing:Within 2 hours centrifuge and aliquot 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:7 days refrigerated; up to 8 months frozen at -20°C.
Test Performed at or Referral Lab Chemistry  (UMMC-East Bank)


Interpretive

Reference Range:
Low risk <1.0 mg/L
Average risk 1.0-3.0 mg/L
High risk >3.0 mg/L
Acute Inflammation >10.0 mg/L 
   
Use:C-Reactive Protein, Cardiac Risk is often referred to as high-sensitivity CRP (hs-CRP). This test measures the much lower amounts of CRP in the blood of normal individuals who lack overt inflammatory conditions. It is used to assess cardiac risk. Adding measurement of hs-CRP to results from a fasting lipid panel further improves the identification of patients at risk for cardiovascular events. Individuals with comparable LDL-and HDL-cholesterols who have hs-CRP in the higher part of the normal range (e.g. greater than 3.0 mg/L) are at higher risk for developing atherosclerotic disease events than those with hs-CRP results in the lower part of the reference range (e.g. less than 1.0 mg/L). When using the assay for risk assessment, patients with persistently unexplained, marked elevation of hsCRP (>10 mg/L) after repeated testing should be evaluated for non-cardiovascular etiologies.


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