Glutamic Acid Decarboxylase Antibody


Sunquest Code:GAD  
Epic Code:LAB3488Epic Name:Glutamic Acid Decarboxylase Antibody
Synonyms:GAD65
Methodology:Enzyme-linked immunosorbent assay
CPT Code:83519
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-3 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Plasma, grossly hemolyzed specimens


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.5 mL minimum. Store in freezer.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2001771


Interpretive

Reference Range:0.0-5.0 Kronos Units/mL
A value greater than 5.0 Kronos Units/mL is considered postive for Glutamic Acid Decarboxylase Antibody. Kronos Units = U/mL
Use:GAD antibodies are present in the majority of individuals with new-onset diabetes and in individuals in the prediabetic phase of the disease. GAD antibodies appear early in the disease process prior to clinical symptoms and can be used to produce who will develop IDDM. Because GAD antibody is present in association with islet cell destruction, it can also be utilized to differentiate IDDM from non-insulin dependent diabetes (NIDDM). The development of GAD antibody in NIDDM patients can be useful to determine which patients may later require insulin therapy.


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