Metanephrines, Plasma, Free

Sunquest Code:METPLF  
Epic Code:LAB6760Epic Name:Metanephrines, Plasma Free
Synonyms:Metanephrines and Normethnephine, Free
Methodology:Liquid chromatography/tandem mass spectrometry
Test Includes:Metanephrine and Normetanephrine
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-4 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:4 mL
Minimum\Peds Volume:2 mL
Container:Purple (EDTA) on ICE (Green (sodium heparin, no gel) on ICE)
Patient Preparation:Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection if possible. Collection of the specimen after the patient has rested for 15 minutes in a supine position is recommended.
Causes for Rejection:Plasma separator tubes. Body fluids other than EDTA or heparinized plasma. Non-frozen specimens.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 1 hour of collection 2 mL, 1 mL minimum. Freeze immediately. Avoid hemolysis.
Shipping Instructions:Ship on dry ice.
Stability:Stability: After separation from cells: 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50184


Reference Range:Metanephrine: 0.0-0.89 nmol/L; Normetanephrine: 0.0-0.49 nmol/L
Use:This test is useful in the detection of pheochromocytoma, a rare neuroendocrine tumor. The majority of patients with pheochromocytoma have a plasma normetanephrine concentration in excess of 2.2 nmol/L and/or a metanephrine concentration in excess of 1.1 nmol/L. Increased concentrations of these analytes serve as confirmation for diagnosis. Patients with essential hypertension and plasma concentrations of normetanephrine below 0.9 nmol/L and a metanephrine concentration below 0.5 nmol/L can be excluded from further testing. If clinical suspicion remains, repeat testing or testing for metanephrines in a 24-hour urine specimen should be considered.

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