West Nile Virus Antibodies, IgG and IgM by ELISA, CSF


Sunquest Code:CWNGM  
Epic Code:LAB3415Epic Name:WEST NILE VIRUS IGG AND IGM CSF
Synonyms:Arbvirus; Mosquito Borne Encephalitis; Viral Encephalitis
Methodology:Enzyme-linked immunosorbent assay
CPT Code:86789, 86788
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-8 days.


Collection Instructions

Specimen:CSF
Optimal Volume:2 mL
Minimum\Peds Volume:0.3 mL
Causes for Rejection:Heat inactivated, contaminated or hemolyzed.


Processing and Shipping

Specimen Processing:2 mL, 0.3 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50228 (WNILE CSF)


Interpretive

Reference Range:

 

West Nile Virus Aby, IgG by ELISA, CSF

 

1.29 IV or less:  Negative – No significant level of West Nile virus IgG antibody detected.

1.30-1.50 IV: Equivocal – Questionable presence of West Nile virus IgG antibody detected. Repeat testing in 10-14 days may be helpful.

1.51 IV or greater: Positive – Presence of IgG antibody to West Nile virus detected suggestive of current or past infection.

 

West Nile Virus Aby, IgM by ELISA, CSF

 

0.89 IV or less:  Negative – No significant level of West Nile virus IgM antibody detected.

0.90-1.10 IV: Equivocal – Questionable presence of West Nile virus IgM antibody detected. Repeat testing in 10-14 days may be helpful.

1.11 IV or greater: Positive – Presence of IgM antibody to West Nile virus detected suggestive of current or recent infection.

 

 

 

Use:

This test is intended to be used as a semi-quantitative means of detecting West Nile virus-specific IgG and IgM in CSF samples in which there is a clinical suspicion of West Nile virus infection. This test should not be used solely for quantitative purposes, nor should the results be used without correlation to clinical history or other data. Because other members of the Flaviviridae family, such as St. Louis encephalitis virus show extensive cross-reactivity with West Nile virus, serologic testing specific for these species should also be performed.

 

The detection of antibodies to West Nile virus in cerebrospinal fluid may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.

 

 



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