Ehrlichia Chaffeensis Antibodies, IgG and IgM


Sunquest Code:ERABGM  
Epic Code:LAB3453Epic Name:EHRLICHIA CHAFFEENIS ABYS IGG AND IGM
Order Instructions:For Ehrlichia Antibody Panel also order Anaplasma Phagocytophilum Antibodies, IgG and IgM
Synonyms:HME; Human Monocytic Ehrlichiosis; Tick-borne Diseases
Methodology:Indirect fluorescent antibody
CPT Code:86666
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days.
Special Instructions:Parallel testing is preferred. Label samples as acute or convalescent. Convalescent specimens must be received within 30 days from receipt of the acute specimens.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.3 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Lipemic, hemolytic or contaminated specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.05 mL minimum. Separate serum from cells ASAP. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:51002 (E CHAF ABS)


Interpretive

Reference Range:

Ehrlichia chaffeensis Antibody, IgG by IFA

Less than 1:64 – Negative: No significant level of Ehrlichia chaffeensis IgG antibody detected.

1:64-1:128 – Equivocal: Questionable presence of Ehrlichia chaffeensis IgG antibody detected. Repeat testing in 10-14 days may be helpful.

Greater than or equal to 1:256 – Positive: Presence of IgG antibody to Ehrlichia chaffeensis detected, suggestive of current or past infection.

Ehrlichia chaffeensis Antibody, IgM by IFA

Less than 1:16 – Negative: No significant level of Ehrlichia chaffeensis IgM antibody detected.

Greater than or equal to 1:16 – Positive: Presence of IgM antibody to Ehrlichia chaffeensis detected, suggestive or current or recent infection.

 

 

Use:Human ehrlichiosis is a tick-borne disease caused by rickettsial-like agents. Two forms, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) have been described. HME is often referred to as "spotless" or rashless Rocky Mountain spotted fever, and has been reported in various regions of the United states. The causative agent of HME has been identified as Ehrlichia chaffeensis. Infected individuals produce specific antibodies to Ehrlichia chaffeensis which can be detected by an immunofluorescent antibody (IFA) test.


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