Ehrlichia Chaffeensis Antibodies, IgG and IgM


Sunquest Code:ERABGM  
Epic Code:LAB3453Epic Name:Ehrlichia Chaffeensis Abys IGG and IGM
Synonyms:HME; Human Monocytic Ehrlichiosis; Tick-borne Diseases
Methodology:Indirect fluorescent antibody
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days.
Special Instructions:Parallel testing is preferred. Label samples as acute or convalescent. Convalescent specimens must be received within 30 days from receipt of the acute specimens.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Lipemic, hemolytic or contaminated specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.3 mL minimum. Separate serum from cells ASAP. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 48 hours at room temperature; 2 weeks refrigerated; 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:51002


Interpretive

Reference Range:
Ehrlichia chaffeensis Antibody IgG by IFA
Less than 1:64 Negative. No significant level of Ehrlichia chaffeensis IgG antibody detected.
1:64-1:128 Equivocal. Questionable presence of Ehrlichia chaffeensis IgG antibody detected. Repeat testing in 10-14 days may be helpful.
Greater than or equal to 1:256 Positive. Presence of IgG antibody to Ehrlichia chaffeensis detected, suggestive of current or past infection.
 
Ehrlichia chaffeensis Antibody IgM by IFA
Less than 1:16 Negative. No significant level of Ehrlichia chaffeensis IgM antibody detected.
Greater than or equal to 1:16 Positive. Presence of IgM antibody to Ehrlichia chaffeensis detected, suggestive of current or past infection.
 
Use:Human ehrlichiosis is a tick-borne disease caused by rickettsial-like agents. Two forms, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) have been described. HME is often referred to as "spotless" or rashless Rocky Mountain spotted fever, and has been reported in various regions of the United states. The causative agent of HME has been identified as Ehrlichia chaffeensis. Infected individuals produce specific antibodies to Ehrlichia chaffeensis which can be detected by an immunofluorescent antibody (IFA) test.


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