Myelin Associated Glycoprotein (MAG) Autoantibody


Sunquest Code:MAGAB  
Epic Code:LAB7016Epic Name:MAG and SGPG Antibodies, IgM
Synonyms:MAG Dual Antigen Autoantibody; Myelin Associated Glycoprotein (MAG) and Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies IgM
Methodology:Enzyme-linked immunosorbent assay
CPT Code:83516 x2
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-10 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been approved or cleared by the US Food and Drug Administration (FDA). The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.4 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Urine, contaminated, heat-inactivated, hemolyzed, icteric or severely lipemic specimens,


Processing and Shipping

Specimen Processing:Within 2 hours of collection, centrifuge and aliquot 0.5 mL, 0.1 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2004412


Interpretive

Reference Range:

 

Myelin Associated Glucoprotein (MAG) Antibody, IgM: Less than 1000 TU

Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM: Less than 1.00 IV

 

Use:An elevated IgM antibody concentration greater than 999 TU against myelin-associated glycoprotein (MAG) suggests active demyelination in peripheral neuropathy. A normal concentration (less than 999 TU) generally rules out an anti-MAG antibody-associated peripheral neuropathy. The majority of sulfate-3-glucoronyl paragloboside (SGPG) IgM positive sera will s how reactivity against MAG. Patients who are SGPG IgM positive and MAG IgM negative may have multi-focal motor neuropathy with conduction block. TU = Titer Units.


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