Bethesda Assay for Factor 9 with normal plasma


Sunquest Code:BETH4  
Epic Code:LAB3319Epic Name:Bethesda for Factor 9
Synonyms:Factor 9 Hemophilia Antibody; Factor 9 Inhibitor; Hemophilia B Inhibitor; Bethesda Assay for Factor IX
Methodology:Measurement of residual Factor 9 on mixtures of patient plasma mixed with normal pooled plasma.
CPT Code:----------CPTCODES HERE----------
Turnaround Time:Specimen is accepted and processed 24 hours/day, 7 days/week. Test is performed as needed; results are reported within 2-4 days.
Special Instructions:Indicate on request form when the last Factor 9 infusion was administered. If Thrombin Time is >60 seconds. Bethesda Assay for Factor 9 will be cancelled with the following comment: SPECIMEN CANCELLED, INTERFERING SUBSTANCES DETECTED. CORRELATION WITH MEDICATIONS RECOMMENDED.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens



Collection Instructions

Specimen:Blood
Optimal Volume:Three 3 mL tubes, each containing 2.7 mL blood; each filled to fill line on tube.
Minimum\Peds Volume:Two 3 mL tubes, each containing 2.7 mL blood; each filled to fill line on tube.
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tubes or clotted specimens
Contraindications:Factor infusion within the last week.


Processing and Shipping

Specimen Processing:See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab Special Coagulation  (UMMC-East Bank)


Interpretive

Reference Range:0 Bethesda U/mL
Use:The Bethesda assay is designed specifically to measure the concentration of anti-Factor 9 antibodies in patients with hemophilia B. This test is a modification of that assay. One Bethesda Unit is the amount of antibody that will inactivate 0.5 mL (50%) of Factor 9.


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