Thiopurine Methyltransferase (TPMT) Genotyping, 4 Variants


Sunquest Code:TPMTG  
Epic Code:LAB6988Epic Name:Thiopurine Methyltransferase Genotyping
Synonyms:TPMT (Thiopurine Methyltransferase) Genetic Assessment (Genotype)
Methodology:Polymerase chain reaction (PCR)/Fluorescence monitoring
CPT Code:81401
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 5-10 days.
Special Instructions:A signed informed consent in the patient's medical record is required; the consent should not be sent to the laboratory. The link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors.
Compliance:

The performance characteristics of this test were validated by ARUP Laboratories, Inc. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing.

Associated Links:

Genetic Testing Consent Form



Collection Instructions

Specimen:Whole Blood
Optimal Volume:3 mL
Minimum\Peds Volume:1 mL
Causes for Rejection:Plasma or serum. Heparinized specimens.


Processing and Shipping

Specimen Processing:Whole blood. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2012233


Interpretive

Reference Range:By report.
Use:Asses risk, due to genetics, for severe myelosuppression with standard dosing of thiopurine drugs. Appropriate for pre- or post-therapeutic assessments. Preferred test for patients with recent heterologous blood transfusion. Can be performed irrespective of thiopurine therapy.


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