Cyclosporine Area Under the Curve


Sunquest Code:CYAUC  
Epic Code:LAB3050Epic Name:Cyclosporine AUC Calculation
Synonyms:Cyclosporine AUC
Methodology:Liquid chromatography/tandem mass spectrometry
Turnaround Time:Performed daily; results are reported the next day.
Special Instructions:Collect drug levels at baseline, 2 hours, 3 hours and 4 hours post dose. Order as individual levels and send to laboratory immediately following collection. Only order one CYAUC (area under the curve) calculation per patient.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Purple (EDTA) (Green (lithium heparin, no gel), Green (sodium heparin, no gel))
Collection Instructions:Collect levels at baseline, 2 hours, 3 hours and 4 hours post dose.
Causes for Rejection:Collected in gel tube; clotted specimen.


Processing and Shipping

Specimen Processing:Whole blood. Do not process. Store in refrigerator.
Shipping Instructions:Ship at room temperature.
Stability:Specimens are stable refrigerated or at room temperature for at least two weeks.
Test Performed at or Referral Lab Drug Analysis  (UMMC-East Bank)


Interpretive

Therapeutic Range:4000-6000 ug*h/L
Use:Pharmacokinetics of cyclosporine.


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