Anti-Neuronal Nuclear Antibodies, IgG

Sunquest Code:NNAB  
Epic Code:LAB6012Epic Name:Anti-Neuronal Nuclear Antibody
Synonyms:Anti Hu, Anti Ri and Anti Yo; Anti-Hu, Anti-Ri and Anti-Yo; Anti Neuronal; Antineuronal
Test Includes:Anti Hu, Anti Ri and Anti-Yo
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-8 days.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been approved or cleared by the US Food and Drug Administration (FDA). The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:0.5 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Plasma. Hemolyzed, lipemic or contaminated specimens.

Processing and Shipping

Specimen Processing:Centrifuge within 2 hours of collection and aliquot 1 mL, 0.15 mL minimum.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: 24 hours at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2007963


Reference Range:None detected.
Use:This immunoblot test detects IgG antibodies to Hu, Ri and Yo. Only antibodies detected are reported in the result field. These markers aid in the discrimination between true paraneoplastic disorders and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and fallopian tube and with breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. The presence of one or more of these antibodies supports the clinical diagnosis of paraneoplastic syndrome and leads to a focused search for underlying PNS and should lead to a focused search for the underlying neoplasm.

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