Neuronal Nuclear Antibodies IgG Immunoblot


Sunquest Code:NNABG  
Epic Code:LAB8230Epic Name:Neuronal Nuclear Ab IgG Immunoblot
Synonyms:Anti Hu, Anti Ri and Anti Yo; Anti-Hu, Anti-Ri and Anti-Yo; Anti Neuronal; Antineuronal
Methodology:Immunoblot
Test Includes:Anti Hu, Anti Ri and Anti-Yo and Anti Tr/DNER
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-4 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Plasma. Hemolyzed, lipemic or contaminated specimens.


Processing and Shipping

Specimen Processing:Centrifuge within 2 hours of collection and aliquot 1 mL, 0.30 mL minimum.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 48 hours at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3002917


Interpretive

Reference Range:Negative
Use:This test detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens.
 Antineuronal antibodies serve as markers that aid in disriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and fallopian tube and with breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr (DNER) is associated with Hodgkin's lymphoma. The presence of one or more of these antibodies supports the clinical diagnosis of PND and leads to a focused search for for the underlying neoplasm.


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