Anti-Neuronal Nuclear Antibodies, IgG - LG4311 Cancel and reorder as ARMISC


Sunquest Code:NNAB  
Epic Code:LAB6012Epic Name:Anti-Neuronal Nuclear Antibody
Order Instructions:Cancel and reorder as ARMISC.
Synonyms:Anti Hu, Anti Ri and Anti Yo; Anti-Hu, Anti-Ri and Anti-Yo; Anti Neuronal; Antineuronal
Methodology:Immunoblot
Test Includes:Anti Hu, Anti Ri and Anti-Yo and Anti Tr/DNER
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-4 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been approved or cleared by the US Food and Drug Administration (FDA). The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel) (Red (no gel))
Causes for Rejection:Plasma. Hemolyzed, lipemic or contaminated specimens.


Processing and Shipping

Specimen Processing:Centrifuge within 2 hours of collection and aliquot 1 mL, 0.30 mL minimum.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 48 hours at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3002917


Interpretive

Reference Range:Negative
Use:This test detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens.
 Antineuronal antibodies serve as markers that aid in disriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and fallopian tube and with breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr (DNER) is associated with Hodgkin's lymphoma. The presence of one or more of these antibodies supports the clinical diagnosis of PND and leads to a focused search for for the underlying neoplasm.


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